RESEARCH PROJECT

Below are listed all research projects funded by the Foundation from 2002 to today, divided by scientific area. The FFC Ricerca Scientific Committee selects them according to two fundamental goals: improving the available treatments to increase the quality of life of pwCF; finding a definitive cure for CF acting on the basic defect.

NETWORK PROJECTS

AREA 3 Bronchopulmonary infection

GMSG#1/2025

Developing PNAs to Block Essential Bacterial Genes and Create New Antimicrobial Therapies

€ 177.450 funds raised

€ 177.450
Goal

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AREA 1 Therapies to correct the underlying defect

FFC#1/2025

Understanding the process of epithelial-mesenchymal transition to preserve tissue function and reduce long-term complications (e.g. cancer)

€ 209.897 funds raised

€ 209.897
Goal

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AREA 1 Therapies to correct the underlying defect

FFC#2/2025

Developing RNA-targeted therapies to regulate gene expression and restore CFTR synthesis

€ 173.250 funds raised

€ 173.250
Goal

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STRATEGIC PROJECTS

FFC/TFCF – Preclinical phase

The Task Force for Cystic Fibrosis project has identified new compounds that are highly active in vitro in correcting the CFTR protein. Among them, the most potent and promising compound, ARN23765, has been selected for preclinical development, an essential step towards its potential use in clinical trials in humans.

€ 0 funds raised

€ 2.644.000
Goal

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FFC Ricerca 2025 strategic project: De-risking GY

Assessing the safety and clinical potential of GY971, an anti-inflammatory compound for cystic fibrosis

€ 115.812 funds raised

€ 115.812
Goal

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FFC Ricerca 2025-2028 strategic project: MindKids-CF

Development of screening and monitoring tools for anxiety, depression, and behavior Problems in Italian Children with Cystic Fibrosis under 12 Years of Age

€ 169.596 funds raised

€ 169.596
Goal

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