STRATEGIC PROJECTS

Strategic Projects

Strategic projects are initiatives that the Foundation launches in a more targeted and detailed manner, with the aim of promoting promising scientific research and raising public awareness about the issues related to cystic fibrosis:

Molecules 3.0 for Cystic Fibrosis – New pharmacological modulators for the recovery of the mutated CFTR protein. Phase 1Phase 2Phase 3Phase 4

Kaftrio in Real Life – Effectiveness and safety of Kaftrio in real life: an Italian observational and multicenter study. Phase 1Phase 2

1 in 30 and You Don’t Know It – Awareness project on the carrier testing for cystic fibrosis. Phase 1Phase 2Phase 3Phase 4

Task Force for Cystic Fibrosis – New and more effective correctors of the mutated CFTR protein

Experts Together – Improving integration and alignment of goals between the CF community and the world of science and research

GenDel-CF – Gene transfer strategies in the lungs for the treatment of cystic fibrosis

MindKids-CF – Study on mental health in children with cystic fibrosis

De-risking GY – Assessing the safety and clinical potential of GY971, an anti-inflammatory compound for cystic fibrosis

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FFC/TFCF – Preclinical phase

The Task Force for Cystic Fibrosis project has identified new compounds that are highly active in vitro in correcting the CFTR protein. Among them, the most potent and promising compound, ARN23765, has been selected for preclinical development, an essential step towards its potential use in clinical trials in humans.
€ 0 funds raised
0%
€ 2.644.000
Goal

FFC Ricerca 2025 strategic project: De-risking GY

Assessing the safety and clinical potential of GY971, an anti-inflammatory compound for cystic fibrosis
€ 115.812 funds raised
0%
€ 115.812
Goal

FFC Ricerca 2025-2028 strategic project: MindKids-CF

Development of screening and monitoring tools for anxiety, depression, and behavior Problems in Italian Children with Cystic Fibrosis under 12 Years of Age
€ 169.596 funds raised
0%
€ 169.596
Goal

FFC/TFCF – Phase 3

The main objective of the Task Force for Cystic Fibrosis project is to develop new correctors and enhancers for the F508del mutation and, potentially, for other CF mutations. The project, which is expected to last three and a half years, is divided into three phases: 1) Hit identification; 2) Hit-to-lead; 3) Lead optimisation.
€ 0 funds raised
0%
€ 680.000
Goal

FFC/TFCF – Phase 2

The main objective of the Task Force for Cystic Fibrosis project is to develop new correctors and enhancers for the F508del mutation and, potentially, for other CF mutations. The project, which is expected to last three and a half years, is divided into three phases: 1) Hit identification; 2) Hit-to-lead; 3) Lead optimisation.
€ 0 funds raised
0%
€ 370.000
Goal

FFC/TFCF – Phase 1

The main objective of the Task Force for Cystic Fibrosis project is to develop new correctors and enhancers for the F508del mutation and, potentially, for other CF mutations. The project, which is expected to last three and a half years, is divided into three phases: 1) Hit identification; 2) Hit-to-lead; 3) Lead optimisation.
€ 0 funds raised
0%
€ 200.000
Goal

FFC Ricerca 2025 strategic project: 1 in 30 and you don’t know it. Phase 4

An information and awareness campaign on the test of the healthy carrier of cystic fibrosis.
€ - funds raised
0%
€ 180.000
Goal

FFC Ricerca 2024-2027 Strategic Project: GenDel-CF

Tackling gene delivery in lungs for the treatment of cystic fibrosis.
€ 110.207 € funds raised
0%
€ 1.870.207 €
Goal

FFC Ricerca 2024-2025 Strategic Project: Molecules 3.0 for CF. Phase 5

Advanced functional validation of CFTR new modulators and selection of lead candidates for further development
€ 149.100 funds raised
0%
€ 149.100
Goal