RESEARCH PROJECT

Below are listed all research projects funded by the Foundation from 2002 to today, divided by scientific area. The FFC Ricerca Scientific Committee selects them according to two fundamental goals: improving the available treatments to increase the quality of life of pwCF; finding a definitive cure for CF acting on the basic defect.

NETWORK PROJECTS

AREA 1 Therapies to correct the underlying defect

GMRF#1/2026

Exploring the role of PKD1 in promoting CFTR stability and function at the cell surface

€ 105.000 funds raised

€ 105.000
Goal

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AREA 1 Therapies to correct the underlying defect

FFC#1/2026

Mapping proteins regulating CFTR mRNA stability to identify new therapeutic targets for nonsense mutations

€ 209.890 funds raised

€ 209.890
Goal

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AREA 2 Personalized therapies

FFC#2/2026

Evaluating the potential of phosphodiesterase inhibitors to enhance the efficacy of CFTR modulators and support personalized therapeutic approaches

€ 210.000 funds raised

€ 210.000
Goal

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STRATEGIC PROJECTS

FFC Ricerca 2026-2030 strategic project: Restart-CFTR

A new strategy based on ACE-tRNAs and their targeted delivery to airway cells

€ 1.584.428 funds raised

€ 1.584.428
Goal

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FFC/TFCF – Preclinical phase

The Task Force for Cystic Fibrosis project has identified new compounds that are highly active in vitro in correcting the CFTR protein. Among them, the most potent and promising compound, ARN23765, has been selected for preclinical development, an essential step towards its potential use in clinical trials in humans.

€ 0 funds raised

€ 2.644.000
Goal

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FFC Ricerca 2025 strategic project: De-risking GY

Assessing the safety and clinical potential of GY971, an anti-inflammatory compound for cystic fibrosis

€ 115.812 funds raised

€ 115.812
Goal

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