Some tens of phages were isolated and characterized and among them six were selected and mixed in a cocktail. This cocktail resulted able to efficiently kill different P. aeruginosa strains in vitro and to overcome bacterial biofilm. Genome analysis of phages sequences was carried out and indicated the absence of indesirable genes, suggesting phages could be used without problems for human therapy. Researchers’ intend now to validate the efficacy of the phage cocktail in two different models in vivo: in mice and in Galleria mellonella larvae. This strategy could have the potential for development as a therapeutic approach to control P. aeruginosa infections in CF patients.