Two chemical compounds named Marimastat and Galardin demonstrated inhibitory activity against the proinflammatory MPS released by P. aeruginosa and thus decreased lung inflammation in wild type and CF mice. Claritromycin, an antibiotic with action mechanism similar to azitromycin, is capable of blocking the synthesis of several Pseudomonas virulence factors. The transgenized IL-8 CF mouse model was validated in this study and may offer some advantages in this field of research.