Mouse MABs engrafted lung, tracheal and intestinal epithelium for up to 6 months in F508delCFTR mice after a single systemic injection. In vitro mMABS are able to express a functional CFTR channel and also in vivo mMABs transplanted KOCfrtm 1 UNC mice express a functional CFTR. Notably when transplanted and engrafted in the epithelium mMABs express typical epithelial markers, thus demonstrating mMAB ability to differentiate in epithelial cells. Finally, the first studies on human MABs demonstrated their ability to express a functional channel.