TRPA1 channels are expressed In the CF epithelium. Inhibition of TRPA1 expression results in a relevant reduction of several cytokines, including IL-8 and the proinflammatory cytokines Il-1beta and TNF-alfa. TRPA1 channels are a relevant part of the pro-inflammatory signalling regulating CF lung inflammation. The results provide the rationale to test the pharmacological inhibitors of TRPA1 channels, in order to intervene in synergy with other drugs in the cure of the lung pathology of CF patients, with the perspective of drug repositioning to cure the CF lung disease.