Milk-derived bovine Lf (bLf) is used as it shows similar structure and functions of human Lf, it is generally recognized as a safe substance by FDA (USA), and it has been successfully employed in clinical trials. BLf loaded-liposomes (bLf-LIPOs) were fully characterized. BLf is efficiently entrapped in liposomes and protected against the activity of trypsin. BLf-LIPOs were no cytotoxic on CFBE(cystic fibrosis bronchial epithelium) cells. In WT mice bLf reduced significantly the inflammatory response and the bacterial load, even if at not significant levels. Researchers expect to consolidate the data on the effect of bLf in WT mice and to evaluate the bLf effects on CF mice. Moreover they want to investigate the effect of aerosolized blf-LIPOs in preclinical animal models. This study represents the basis for the development of product to be administered in humans as aerosol formulation in the treatment of CF airway infection. It will be continued in the extension project FFC#12/2015.