FFC#26/2019

Standardized Ventilation Inflammation Perfusion and Structure (VIPS) MRI platform for monitoring Cystic Fibrosis Lung Disease

FFC#26/2019

Standardized Ventilation Inflammation Perfusion and Structure (VIPS) MRI platform for monitoring Cystic Fibrosis Lung Disease

PRINCIPAL INVESTIGATOR

Giovanni Morana (Ospedale Ca’ Foncello, Dip. Radiologia Diagnostica e Interventistica, Treviso)

RESEARCHERS

5

CATEGORY

AREA 5 Clinical and Epidemiological research

DURATION

2 years

GOAL

€ 75.000 €

RESULTS

Preliminary data were obtained from the analysis of 8 stable CF patients. The images obtained by the FD-MR were analyzed to evaluate their quality.Qualitative tests were conducted on images of the bronchi and intrapulmonary vessels, considering the noise present in the image and the diagnostic quality of the images using a scale from unacceptable (score 1) to excellent (score 5). The most relevant image artifacts were evaluated and to score the airway visibility, a modification was made to the analysis protocol. All images were evaluated anonymously and randomly by an observer with 2 years of experience in lung MRI. MRI images recorded with the Ultra-short echo-time (UTE) technique provided excellent visualization of the bronchi and intrapulmonary vessels. The entire dataset thus obtained can be used to complete the analysis of the collected data. MRI images analyzed with different techniques will soon be compared in stable CF patients to determine disease progression and in patients with exacerbations to evaluate functional changes related to perfusion, ventilation and lung inflammation.

OTHER RESULTS

FFC#1/2023

Tezacaftor, one of the components of Kaftrio, induces an accumulation of dihydroceramides both in vitro and in vivo in animal models

FFC#4/2023

Pseudopaline–aztreonam conjugates exhibited enhanced antimicrobial activity against Pseudomonas aeruginosa compared to aztreonam alone

FFC#10/2023

Several drugs already approved for human use inhibit the growth of P. aeruginosa, its virulence, or its ability to form biofilms in vitro