FFC#27/2018

Use of multivolume MRI instead of ionizing imaging techniques for surveillance in young patients after lung transplantation for cystic fibrosis

FFC#27/2018

Use of multivolume MRI instead of ionizing imaging techniques for surveillance in young patients after lung transplantation for cystic fibrosis

PRINCIPAL INVESTIGATOR

Alessandro Palleschi (Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, Milano)

Partner

Andrea Aliverti (Politecnico di Milano, Dip. Elettronica, Informazione e Bioingegneria)

RESEARCHERS

12

CATEGORY

AREA 5 Clinical and Epidemiological research

DURATION

2 years

GOAL

€ 40.000 €

RESULTS

From August 2018 to September 2019, 35 CF patients from the Milan TransplantationUnit underwent lung transplantation, and 22 of them were enrolled in the study. Of these patients, 17 completed the protocol described in the project, they were subjected to routine post-transplant surveillance examinations which include tests of respiratory function, broncho-alveolar lavage and lung biopsies and computed tomography imaging (CT). In addition, the researchers performed magnetic resonance imaging (MRI) of the lung. These analyses were performed at 3, 6, 12 months and in case of patient complications. The data obtained from the various techniques were organized in a database and analysed with a dedicated algorithm. The results showed a correlation between the MRI data and data obtained from CT and respiratory function. The researchers suggest the use of MRI for the surveillance of post-transplant CF patients as an alternative to the routine protocol in order to avoid patients exposure to ionizing radiation used in techniques such as CT.

OTHER RESULTS

FFC#1/2023

Tezacaftor, one of the components of Kaftrio, induces an accumulation of dihydroceramides both in vitro and in vivo in animal models

FFC#4/2023

Pseudopaline–aztreonam conjugates exhibited enhanced antimicrobial activity against Pseudomonas aeruginosa compared to aztreonam alone

FFC#10/2023

Several drugs already approved for human use inhibit the growth of P. aeruginosa, its virulence, or its ability to form biofilms in vitro