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FFC#26/2014

Impaired secretory IgA and mucosal immunity in cystic fibrosis: contribution to lung pathology and impaired defence against bacterial infection, and role of CFTR-related epithelial changes in the regulation of the receptor-mediated IgA transcytosis

FFC#26/2014

Impaired secretory IgA and mucosal immunity in cystic fibrosis: contribution to lung pathology and impaired defence against bacterial infection, and role of CFTR-related epithelial changes in the regulation of the receptor-mediated IgA transcytosis

PRINCIPAL INVESTIGATOR

Charles Pilette (Université Catholique de Louvain, Brussels)

Partner

Virginia De Rose (Dip. di Scienze Biologiche e Cliniche, Università di Torino)

RESEARCHERS

5

CATEGORY

AREA 4 Lung inflammation

DURATION

2 years

GOAL

€ 48.000

RESULTS

Total IgA and Pseudomonas specific IgA were increased in sputum from CF patients as compared to control subjects. Bronco-epithelial pIgR expression was upregulated in CF lungs as compared to controls. These data indicate that lung S-IgA immunity is preserved in CF.

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