This multicentric study allowed to perform 406 OGTTs with insulin secretory and C-peptide data. Insulin and c-peptide assays provided comparable measures among centers. Modeling is underway as well as statistical analysis for reference values and relationship with clinically relevant biomarkers. Preliminary analysis from the Milan group (inclusive of previously collected data) showed that Glucose Sensitivity and Insulin concentration at 30’ are the main correlates of lung function and long term predictors of CFRD and adult height. Sex and age-adjusted nomograms of OGTT parameters will be carried out and implemented among Italian centers: they are proposed as powerful tools to describe the glucose tolerance defects natural history, to predict future CFRD, nutritional and respiratory decay and to set a rational basis for treatment. A collaboration has been set with a US multicenter group, that will replicate the project protocol and analysis in an equal number of patients, with the aim to produce common international reference values.
Pubblications
Colombo C, Alicandro G, Gambazza S et al. “Ventilation inhomogeneity is associated with OGTT-derived insulin secretory defects in cystic fibrosis” Pediatr Pulmonol 2018 Dec 21. doi: 10.1002/ppul.24212. [Epub ahead of print]
Congress abstracts
– Nazzari E, Guarise R, Mileto P et al. “Relationship between glucose and insulin response during an oral glucose tolerance test (OGTT) and lung clearance index in cystic fibrosis patients” XIII Congresso Nazionale SIFC, Napoli, 22-25 Novembre 2017