Developed skills and lines of research
Giovanni Taccetti received his MD from the University of Florence in 1983 and completed his residency in Pediatrics at the same university in 1988. He has worked as a hospital pediatrician since 1988 and, in April 1992, joined the Tuscan Regional Cystic Fibrosis Center at Meyer Children’s Hospital in Florence. From January 2019 to May 31, 2025, he served as Director of the Center. In close collaboration with the Center’s laboratory staff, he coordinated research programs with a strong focus on the integration of clinical care and laboratory-based research. Dr. Taccetti has authored numerous scientific publications and presented extensively at national and international conferences on cystic fibrosis. He has served as principal investigator or research partner in multiple projects in the field, with research interests including clinical trials of innovative therapies; early treatment strategies for methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in cystic fibrosis; pulmonary infections caused by Pseudomonas aeruginosa and the Burkholderia cepacia complex; development of diagnostic tests; studies of the lung microbiome; multidrug-resistant bacterial strains in cystic fibrosis; and the impact of novel therapies on pulmonary microbial flora.
Projects funded by FFC Ricerca as Principal Investigator
FFC#30/2015
Pseudomonas aeruginosa eradication in patients with cystic fibrosis: a randomised multicentre study comparing classic treatment protocols with classic treatment together with antibiotic treatment of upper airways
FFC#20/2012
Early antibiotic treatment for MRSA eradication in cystic fibrosis patients: a randomised multicentre study
FFC#17/2007
Early antibiotic treatment in Pseudomonas aeruginosa eradication in cystic fibrosis patients: a randomised policentric study on two different protocols
FFC#18/2004
Early eradication of P. Aeruginosa and subsequent colonization in Cystic Fibrosis patients
Projects financed by FFC Ricerca as a partner
FFC#8/2012
Investigation of cystic fibrosis airway microbiome in patients showing a severe decline in lung function and not responding to conventional antimicrobial therapy
FFC#10/2014
Investigating the airway microbiome in cystic fibrosis patients with a severe decline in lung function: an opportunity for a personalized microbiomebased therapy
FFC#9/2003
Development of a rapid diagnostic test to discriminate B. cepacia complex species and genomovars in routine clinical analysis involving CF patients
Publications from FFC Research projects
Taccetti G, Campana S, Festini F et al. Early eradication therapy against Pseudomonas aeruginosa in cystic fibrosis patients. Eur Respir J. 2005 Sep;26(3):458-61.
Taccetti G, Bianchini E, Cariani L, et al. Early antibiotic treatment for Pseudomonas aeruginosa eradication in patients with cystic fibrosis: a randomised multicentre study comparing two different protocols. Thorax. 2012 Oct;67(10):853-9. Epub 2012 Feb 29.
Dolce D, Cariani L, Campana S, et al. Evaluation of specific immune response in early P. aeruginosa infection in cystic fibrosis patients. J Cyst Fibros, 2014 Jan;13(1):116-7. doi: 10.1016/j.jcf.2013.08.003. Epub 2013 Sep 7.
Dolce D, Neri S, Grisotto L, et al. Methicillin-resistant Staphylococcus aureus eradication in cystic fibrosis patients: A randomized multicenter study. PLoS One. 2019 Mar 22;14(3):e0213497. doi: 10.1371/journal.pone.0213497. eCollection 2019.
Giovanni Taccetti, Daniela Dolce, Silvia Campana, Novella Ravenni, Michela Francalanci, Gianfranco Mergni, Tommaso Orioli, Lucia Zavataro, Cesare Braggion, Giuseppe Tuccio, Carla Colombo, Lisa Cariani, Daniela Girelli, Mirella Collura, Maria Antonietta Orlando, Giovanna Pisi, Maria Luisa Villani, Francesco Longo. Pseudomonas aeruginosa eradication in patients with cystic fibrosis: a randomised multicentre study comparing classic treatment protocols with classic treatment together with antibiotic treatment of upper airways. The Proceedings of the 16th Italian Convention of Investigators in Cystic Fibrosis. Multidisciplinary Respiratory Medicine, 2019, 14 (Suppl 1):5