Developed skills and lines of research
Martina Rossitto graduated in Biology and Human Evolution in 2012 from the University of Rome “Tor Vergata” and received her PhD in Biomedical Sciences and Technologies in 2017 from Roma Tre University with a project aimed at identifying bacteriophages for the treatment of pulmonary infections caused by Pseudomonas aeruginosa. Since 2012, she has worked at the Microbiology and Immunology Diagnostics Unit of the Bambino Gesù Children’s Hospital (OPBG) in Rome, where she carries out research and diagnostic activities related to the microbiology of people with cystic fibrosis (CF). Since 2019, she has been a research biologist at the Multimodal Laboratory Medicine research unit of OPBG, and manages a research line focused on Pseudomonas aeruginosa in CF. Her main research interests are aimed at implementing molecular techniques for the early identification of this pathogen and using spectroscopy techniques for the evaluation of the clonality of isolates, in order to verify the effectiveness of eradicating antibiotic treatment. Finally, she is studying the evolution of Pseudomonas aeruginosa during years of pulmonary colonization to understand the adaptive strategies of the bacterium in order to improve and personalize therapeutic approaches.
Projects funded by FFC Ricerca as Principal Investigator or as Research Manager
FFC#15/2024
Analysis of the evolution of virulence factors and antimicrobial resistance of Pseudomonas aeruginosa in people with cystic fibrosis
Projects financed by FFC Ricerca as a partner
FFC#21/2011
Phosphodiesterases type-4 (PDE4) as a novel target to reduce neutrophilic lung inflammation in cystic fibrosis
Publications from FFC Research projects
Mattoscio D, Evangelista V, De Cristofaro R et al. Cystic fibrosis transmembrane conductance regulator (CFTR) expression in human platelets: impact on mediators and mechanisms of the inflammatory response. FASEB J. 2010 Oct;24(10):3970-80. doi: 10.1096/fj.10-159921. Epub 2010 Jun 8.
Pieroni L, Finamore F, Ronci M, et al. Proteomics investigation of human platelets in healthy donors and cystic fibrosis patients by shotgun nUPLC-MSE and 2DE: a comparative study. Mol Biosyst, 2011 Mar;7(3):630-9. doi: 10.1039/c0mb00135j. Epub 2010 Nov 12.
Simiele F, Recchiuti A, Mattoscio D, et al. Transcriptional regulation of the human FRR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity. FASEB J 2012 Mar;26(3):1323-33. doi: 10.1096/fj.11-198069. Epub 2011 Nov 30.
Pierdomenico AM, Recchiuti A, Simiele F, et al. MicroRNA-181b regulates ALX/FPR2 receptor expression and proresolution signaling in human macrophages. J Biol Chem, 2015 Feb 6;290(6):3592-600. doi: 10.1074/jbc.M114.592352. Epub 2014 Dec 11.
Romano M, Cianci E, Simiele F, et al. Lipoxins and aspirin-triggered lipoxins in resolution of inflammation. Eur J Pharmacol, 2015 Aug 5;760:49-63. doi: 10.1016/j.ejphar.2015.03.083. Epub 2015 Apr 18.
Totani L, Plebani R, Piccoli A et al. Mechanisms of endothelial cell dysfunction in cystic fibrosis. Biochim Biophys Acta. 2017 Dec;1863(12):3243-3253. doi: 10.1016/j.bbadis.2017.08.011. Epub 2017 Aug 25.
Plebani R, Tripaldi R, Lanuti P et al. Establishment and long-term culture of human cystic fibrosis endothelial cells. Lab Invest. 2017 Nov;97(11):1375-1384. doi: 10.1038/labinvest.2017.74. Epub 2017 Jul 31.