Developed skills and lines of research
Since 2003, Mario Romano has been a Full Professor of Laboratory Medicine at the “G. D’Annunzio” University of Chieti-Pescara. He graduated in Medicine with honors from the University of Messina and specialized in Hematology, working between Italy and England. He was a Visiting Scientist at the Hemostasis and Thrombosis Laboratory, Mario Negri Institute for Pharmacological Research, Milan; and at the Unitè de Recherches en Gènètique Moléculaire et Hèmatologie, I.N.S.E.R.M.-U.91, Créteil, France. He also worked as a Research Associate in Medicine at Harvard Medical School, Brigham and Women’s Hospital, Boston, USA. His research includes: pathophysiology of athero-thrombotic and inflammatory processes; pathophysiology, biosynthetic pathways and receptors of products of the lipoxygenase pathways of arachidonic acid metabolism; role of lipoxygenases in carcinogenesis: he has transferred some of the knowledge acquired in these areas to possible applications in cystic fibrosis. For FFC Ricerca, he has recently focused on the role of the vascular endothelium in inflammation in cystic fibrosis.
Projects funded by FFC Ricerca as Principal Investigator or as Research Manager
FFC#15/2023
Melanocortins to control cystic fibrosis airway inflammation
FFC#29/2018
Identification and validation of circulating microvesicles analysis as a new ex vivo assay to monitor cystic fibrosis disease
FFC#23/2014
Mechanisms and clinical implications of endothelial dysfunction in cystic fibrosis
FFC#19/2013
The role of vascular endothelium in cystic fibrosis inflammation
FFC#17/2012
The role of vascular endothelium in cystic fibrosis inflammation
FFC#22/2010
Platelet-leukocyte interactions in cystic fibrosis inflammation: a window for therapeutical opportunities
FFC#15/2007
Mechanisms of inflammation resolution in cystic fibrosis
FFC #12/2005
Lipoxin A4 formation and signalling in cystic fibrosis
Projects financed by FFC Ricerca as a partner
FFC#21/2011
Phosphodiesterases type-4 (PDE4) as a novel target to reduce neutrophilic lung inflammation in cystic fibrosis
Publications from FFC Research projects
Mattoscio D, Evangelista V, De Cristofaro R et al. Cystic fibrosis transmembrane conductance regulator (CFTR) expression in human platelets: impact on mediators and mechanisms of the inflammatory response. FASEB J. 2010 Oct;24(10):3970-80. doi: 10.1096/fj.10-159921. Epub 2010 Jun 8.
Pieroni L, Finamore F, Ronci M, et al. Proteomics investigation of human platelets in healthy donors and cystic fibrosis patients by shotgun nUPLC-MSE and 2DE: a comparative study. Mol Biosyst, 2011 Mar;7(3):630-9. doi: 10.1039/c0mb00135j. Epub 2010 Nov 12.
Simiele F, Recchiuti A, Mattoscio D, et al. Transcriptional regulation of the human FRR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity. FASEB J 2012 Mar;26(3):1323-33. doi: 10.1096/fj.11-198069. Epub 2011 Nov 30.
Pierdomenico AM, Recchiuti A, Simiele F, et al. MicroRNA-181b regulates ALX/FPR2 receptor expression and proresolution signaling in human macrophages. J Biol Chem, 2015 Feb 6;290(6):3592-600. doi: 10.1074/jbc.M114.592352. Epub 2014 Dec 11.
Romano M, Cianci E, Simiele F, et al. Lipoxins and aspirin-triggered lipoxins in resolution of inflammation. Eur J Pharmacol, 2015 Aug 5;760:49-63. doi: 10.1016/j.ejphar.2015.03.083. Epub 2015 Apr 18.
Totani L, Plebani R, Piccoli A et al. Mechanisms of endothelial cell dysfunction in cystic fibrosis. Biochim Biophys Acta. 2017 Dec;1863(12):3243-3253. doi: 10.1016/j.bbadis.2017.08.011. Epub 2017 Aug 25.
Plebani R, Tripaldi R, Lanuti P et al. Establishment and long-term culture of human cystic fibrosis endothelial cells. Lab Invest. 2017 Nov;97(11):1375-1384. doi: 10.1038/labinvest.2017.74. Epub 2017 Jul 31.