Developed skills and lines of research
Valeria Raia graduated in Medicine in 1979 and specialized in Pediatrics in 1983. Since 2011, she has been an Associate Professor of Pediatrics at the University of Naples Federico II and the Director of the Regional Cystic Fibrosis Center of Campania. Her interest in cystic fibrosis research began in 1986 when she started studying the pathogenesis of the disease, particularly the characterization of chronic duodenal inflammation, the modulation of inflammatory responses in ex vivo models, and the genotype-phenotype correlation. Currently, she investigates the molecular mechanisms of inflammation, the modulation of the inflammatory response in nasal mucosa, the effects of probiotics on lung disease, and respiratory infections.
Projects funded by FFC Ricerca as Principal Investigator or as Research Manager
FFC#15/2012
The Heme-oxygenase 1 (HO-1) as modulator of Cystic Fibrosis lung disease
FFC#16/2004
Nasal polyps of Cystic Fibrosis patients as an ex vivo model to study inflammation and its modulation via the inhibition of the p-38 MAP-kinase pathway: implications for therapy
Projects financed by FFC Ricerca as a partner
FFC#8/2022
Targeting the STING/Transglutaminase 2-regulated Interferon response as a novel host-direct approach to fight bacterial infections in cystic fibrosis
FFC#15/2020
Targeting the STING/Transglutaminase 2-regulated Interferon response as a novel host-direct approach to fight bacterial infections in Cystic Fibrosis
FFC#4/2019
Restoring defective proteostasis in Cystic Fibrosis: novel strategies for F508del-CFTR repair
FFC#27/2015
Intra-individual biological variation in sweat chloride concentrations
FFC#20/2012
Early antibiotic treatment for MRSA eradication in cystic fibrosis patients: a randomised multicentre study
Publications from FFC Research projects
- Raia V, Maiuri L, Ciacci C, et al. Inhibition of p38 mitogen activated protein kinase controls airway inflammation in cystic fibrosis. Thorax, 2005 Sep;60(9):773-80. Epub 2005 Jun 30.
- Zhang PX, Murray TS, Villella VR, et al. Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localizationin lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator. J Immunol 2013 May 15;190(10):5196-206. doi: 10.4049/jimmunol.1201607. Epub 2013 Apr 19.