Lueck John D.

Developed skills and lines of research

John D. Lueck obtained a Bachelor’s degree in Biology from Bradley University (Illinois) and then completed a Master’s degree in Pharmacology (2003) and a PhD in Physiology (2007) at the University of Rochester. He continued his training at the same university with a postdoctoral fellowship focusing on ion channels, whilst at the University of Iowa he specialised in muscular dystrophies and tRNA biology.

He is an Associate Professor in the Department of Pharmacology and Physiology at the University of Rochester. Since 2018, he has headed his own research laboratory at the same university, where he also serves as Director of Graduate Studies for the PhD programme in Cell and Molecular Pharmacology and Physiology and is a member of the RNA Research Center and Lung Biology and Disease Program.

His research focuses on how genetic mutations alter the function of ion channels in muscle and lung tissue, and his scientific work centres in particular on the use of engineered tRNAs, known as ACE-tRNAs, as a potential therapeutic approach for cystic fibrosis and other diseases associated with nonsense mutations. By combining membrane biophysics, molecular biology, protein biochemistry and genetics, his research aims to elucidate the molecular basis of genetic disorders in order to translate these findings into the development and in vivo validation of innovative new therapeutic strategies.

Projects funded by FFC Ricerca as Principal Investigator

Restart-CFTR
Overcoming stop mutations to restore CFTR protein production

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Developed skills and lines of research

Projects funded by FFC Ricerca as Principal Investigator