Developed skills and lines of research

Marco Lucarelli graduated in Biological Sciences in 1986 at La Sapienza University of Rome. In 1988, he passed the state examination to qualify as a Biologist, and in 1992, he specialized in Clinical Pathology at the same university. He is currently an Associate Professor at the Department of Cellular Biotechnologies and Hematology at Policlinico Umberto I. His research focuses on molecular genetics, particularly in cystic fibrosis, with clinical-diagnostic applications. In the CF field, he has conducted studies on the role of ENaC (sodium channel) to determine whether alterations in ENaC gene expression could cause a form of CF or modulate its severity and whether the channel’s activity can be targeted therapeutically.

Projects funded by FFC Ricerca as Principal Investigator or as Research Manager

FFC#8/2021
Theratyping of cystic fibrosis

FFC#3/2012
Study of the pathogenetic and therapeutic role of the Epithelial Na+ channel (ENaC) in CF and CF-like disease

Projects financed by FFC Ricerca as a partner

FFC#8/2020
Establishment of Conditionally Reprogrammed Airway Epithelial Stem Cell cultures from nasal epithelia of Cystic Fibrosis patients: exploring response to CFTR-modulating drugs for correlation with genetic profile (theratyping) and restoring CFTR function through gene editing approaches

FFC#12/2018
Establishment of Conditionally Reprogrammed Airway Epithelial Stem Cell cultures from nasal epithelia of Cystic Fibrosis patients: exploring response to CFTR-modulating drugs for correlation with genetic profile (theratyping) and restoring CFTR function through gene editing approaches

FFC#1/2010
Molecular and functional study of the epithelial Na+ channel (ENaC) in CF and CF-like disease

FFC#5/2005
CFTR gene correction in human embryonic stem cells mediated by Small Fragment Homologous Replacement (SFHR)