Developed skills and lines of research
Giuseppe Castaldo earned his degree with honors in Clinical Biochemistry in 1990 at the University of Naples Federico II. Since 2000, he has been a full professor in the Department of Molecular Medicine and Medical Biotechnology at the same university. He also served as Dean of the Faculty of Sciences at the University of Molise from 2002 to 2006, when he became a full professor of Laboratory Medicine Science and Technology at the School of Medicine, University of Naples Federico II.
Giuseppe Castaldo is head of the research and diagnostics laboratory, which is involved in molecular analyses (including prenatal diagnostics) for several dozen genetic diseases. The laboratory employs about twenty researchers. He has authored more than 80 publications in peer-reviewed international journals. In the field of cystic fibrosis, his work focuses on new molecular genetic investigations for diagnosing atypical forms of the disease and studying the function of novel or poorly understood mutations.
Projects funded by FFC Ricerca as Principal Investigator or as Research Manager
FFC#7/2013
Nasal epithelial cells as a novel diagnostic approach for cystic fibrosis and CFTR related-disorders
FFC #19/2007
Molecular analysis of genes encoding CFTR interactors of SLC26 family in CF patients
FFC#5/2004
Screening of CFTR gene rearrangements in Italian CF patients
Projects financed by FFC Ricerca as a partner
FFC#9/2020
Theratyping of rare CFTR genotypes for treatment with CFTR modulators
FFC#16/2004
Nasal polyps of Cystic Fibrosis patients as an ex vivo model to study inflammation and its modulation via the inhibition of the p-38 MAP-kinase pathway: implications for therapy
Publications from FFC Research projects
Salvatore D, Tomaiuolo R, Abate R et al., Cystic fibrosis presenting as metabolic alkalosis in a boy with the rare D579G mutation, Journal of Cystic Fibrosis, 2004, 3(2):135-6
Raia V, Maiuri L, Ciacci C et al., Inhibition of p38 mitogen activated protein kinase controls airway inflammation in cystic fibrosis, Thorax, 2005, 60(9):773-80
Bombieri C, Bonizzato A, Castellani C et al., Frequency of large CFTR gene rearrangements in Italian CF patients, European Journal of Human Genetics, 2005, 13(5):687-9
Tomaiuolo R, Sangiuolo F, Bombieri C et al., Epidemiology and a novel procedure for large scale analysis of CFTR rearrangements in classic and atypical CF patients: a multicentric Italian study, Journal of Cystic Fibrosis, 2008, 7(5):347-51
Amato F, Bellia C, Cardillo G et al., Extensive molecular analysis of patients bearing CFTR-related disorders, J Mol Diagn, 2012, 14(1):81-9
Giordano S1, Amato F, Elce A, et al., Molecular and functional analysis of the large 5′ promoter region of CFTR gene revealed pathogenic mutations in CF and CFTR-related disorders, J Mol Diagn, 2013, 15(3):331-40
Di Lullo AM Scorza M Amato F. An “ex vivo model” contributing to the diagnosis and evaluation of new drugs in cystic fibrosis. Acta Otorhinolaryngol Ital. 2017 Jun;37(3):207-213. doi: 10.14639/0392-100X-1328.