Developed skills and lines of research

Marianne Carlon is an assistant professor at KU Leuven in the Laboratory of Respiratory Thoracic Surgery (BREATHE), affiliated to the Center of Molecular Medicine. Her research interests are the development of causative therapies targeting the genetic defect in cystic fibrosis, making use of innovative in vitro cell models, including patient derived organoids and airway models (organ-on-chip). In collaboration with the university hospitals Leuven (UZ Leuven) thoracic surgery team, she advances the use of ex vivo lung perfusion (EVLP) models as an innovative platform for assessing the safety and efficacy of novel gene delivery systems. Carlon is part of two EU-funded MSCA doctoral training networks (GET-IN and LifeLUNG), providing a large network with societal and economical actors in the fields of gene therapy, EVLP and advanced in vitro lung models for disease modelling and gene therapy efficacy and safety testing. She has been collaborating with Prof. A. Cereseto for many years on gene editing solutions for people living with CF.

Projects funded by FFC Ricerca as Principal Investigator

FFC #3/2025
Optimizing Gene Therapy and Delivery Systems for CF Untreatable Mutations