Starting from the observation that many patients with idiopathic pancreatitis have at least one CFTR mutation, researchers intend to study what other mutant genes are involved in the idiopathic pancreatitis. Moreover, CFTR-related pancreatitis, therefore due to two CFTR mutations even in the absence of typical cystic fibrosis’ clinical features, will also be studied. By using intestinal organoids, developed from rectal epithelial stem cells obtained from minimal biopsy, researchers will evaluate the flows of electrolytes, chloride and bicarbonate, through electrophysiological methods. The aim is to verify the effectiveness of the new CFTR modulators in restoring the normal fluids and ions’ transportation inside the patients’ organoids, with the therapeutic perspective of curing their pancreatitis.