Proteins’ function strictly depends on their three-dimensional conformation. Therefore, details in the structure of CFTR, responsible for Cystic Fibrosis, may be important knowledge to the understanding of its function. This project aims to study the molecular structure of CFTR using small-angle X-ray scattering. With this technique, which does not require any particular treatment of the sample, it is possible to obtain detailed information on the molecular structure of proteins under conditions similar to physiological ones. The structures of the normal CFTR and CFTR carrying the F508del mutation were compared and how correctors modified the molecular conformation of the mutant was deeply investigated. These informations may help to develop new correctors designed in a more rationale way.