Current care model especially in CF medicine is patient-centered and based on the concept of an “expert” patient, that is an active player in his/her care pathway, capable to establish an effective partnership with healthcare team (engagement). Scientific evidences explain the caregivers’ crucial role to sustain an active role of the patient, contributing to increase in therapeutic success potentialities in the short and long term treatment. The primary objective of this study is investigating the engagement of patients, their caregivers and doctors and to investigate different psychosocial variables, potential predictors of this engagement. In the first phase, questionnaires using validated scales will be administrated to all the stakeholders to collect quantitative data. In the second one, in-depth interviews will explore qualitative phenomena in the life stories of patients and adolescent patients’ caregivers. Through an integration between quantitative and qualitative phases, researchers want to define possible clinical guidelines that support engagement in the therapeutic programs for treatment of Cystic Fibrosis.