Recent experimental data suggest that new therapies, such as Kaftrio (Trikafta) and modulators in general, also have activities independent from those exercised on CFTR. The aim of the project is to define whether, how and to what extent Kaftrio affects the susceptibility to antibiotics and the virulence of P. aeruginosa. The researchers aim to define the anti-bacterial effects of Kaftrio and to identify specific strains of P. aeruginosa that may represent a risk factor for the efficacy of this drug. The results obtained could generate recommendations for the use of Kaftrio, also in combination with antibiotic treatment, to optimally transfer the results to the clinical setting.

XIX Convention FFC Ricerca – download here a brief presentation of the project