B. cenocepacia infections are usually ineradicable and represent a serious threat to CF patients. Researchers have identified ERp57, a protein belonging to the Protein Disulfide Isomerase (PDI) family, as a key protein mediating the interaction of B. cenocepacia with epithelial cells. The goal of this study was to evaluate the possibility to inhibit this enzyme and in this way to better control lung infections. Therefore, the most relevant objectives of the study were: 1) to verify if EGCG (Epigallocatechin Gallate inhibitor of ERp57) modulates Burkholderia infection also in immortalized polarized cells and in primary cell monolayers; 2) to carry out a preclinical investigation in wild type and CF mice to evaluate the usefulness of EGCG in the treatment of B. cenocepacia infections.