This project is focused on the study and modulation of alternative targets to CFTR. Through various technological approaches (immunofluorescence assays and confocal microscopy), the researchers aim to evaluate the expression and function of alternative targets in the airways, in order to develop targeted therapeutic approaches. The project involves the use of airway epithelial cells obtained from persons with cystic fibrosis (CF) of various ages, genotypes and clinical conditions and healthy controls using minimally invasive procedures (brushing of the mucous membrane of the nasal cavities). The effect of potentiation or inhibition of these targets on the CF phenotype will also be tested by in vitro studies. Finally, the researchers propose to develop tools and assays for the search for new pharmacological modulators.

XIX Convention FFC Ricerca – download here a brief presentation of the project