Myriocin is a fungal metabolite used in traditional Chinese medicine whose efficacy in modulating cell oxidative stress was demonstrated. Researchers of this project demonstrated that myriocin significantly reduces inflammation and improves response against bacterial and fungal infections in experimental models of cystic fibrosis. Since a therapy based on the anti-oxidant effect of cysteamine in CF was recently approached, now they aim to define the mechanism by which myriocin works and to explore if myriocin it can cooperate with other drugs such as cysteamine and lumacaftor in rescuing CFTR function.