Starting from the two prototype TMA analogues identified preliminarly, the project deals with the design, synthesis and biological evaluation of optimized derivatives of the two lead compounds selected from the first library of TMA analogues. The goals of the project can be outlined in 5 sections: 1) design and synthesis of new TMA analogues; 2) evaluation of phototoxicity and mutagenicity; 3) testing of the anti-inflammatory activity; 4) testing of the effects as CFTR function modulators; 5) derivation of structure-activity relationships aimed at a full comprehension of the structural determinants required to obtain selective properties.